Driving includes multiple complex activities; performance depends on the utilization of both physiological and cognitive capabilities. Short-term factors based on personal lifestyles such as alcohol and drug use are widely known to affect fitness to drive. However, there are long-term factors such as physical or cognitive impairment that account for 6 % of all fatal crashes, while fatigue is a factor in 10-20% of road accidents. Professional drivers in particular are at risk of being involved in a fatigue-related crash. A primary goal of the law enforcement authorities is, therefore, to ensure practical tools for specific and reliable controls “on the road”: in other words to couple road controls with specific tools for evaluating driver’s fitness and thus its performance. FITDrive will rely on a multidisciplinary and ambitious consortium of relevant entities able to cover all the required research areas in a well-balanced way, based on their expertise, prior collaborations (EU H2020 SIMUSAFE project, constituting the base for the research to be developed in FITDrive), state-of-the-art technical background and relevant collaborations to provide the desired impact. FITDrive aims to decrease traffic accidents in 6% by early identifying drivers affected by impairing causes.